of April 5 , 2017 . This information is current as Mouse CD 1 d Phosphatidylinositol Mannoside Binding to

Mouse CD 1 d Phosphatidylinositol Mannoside Binding to Structural Characterization

Mouse Cd1d Phosphatidylinositol Mannoside Binding to Structural Characterization of Mycobacterial

of April 12 , 2017 . This information is current as from Type 1 or Type 2 Effector Cells CellsPrimed but Uncommitted Mouse CD 4 T CD 73 and Ly - 6 A / E Distinguish In Vivo

Phosphatidylinositol mannoside from Mycobacterium tuberculosis binds alpha5beta1 integrin (VLA-5) on CD4+ T cells and induces adhesion to fibronectin.

The pathological hallmark of the host response to Mycobacterium tuberculosis is the granuloma where T cells and macrophages interact with the extracellular matrix (ECM) to control the infection. Recruitment and retention of T cells within inflamed tissues depend on adhesion to the ECM. T cells use integrins to adhere to the ECM, and fibronectin (FN) is one of its major components. We have found...

Nonopsonic binding of Mycobacterium tuberculosis to complement receptor type 3 is mediated by capsular polysaccharides and is strain dependent.

The choice of host cell receptor and the mechanism of binding (opsonic versus nonopsonic) may influence the intracellular fate of Mycobacterium tuberculosis. We have identified two substrains of M. tuberculosis H37Rv, designated H37Rv-CC and -HH, that differed in their modes of binding to complement receptor type 3 (CR3) expressed in transfected Chinese hamster ovary (CHO-Mac-1) cells: H37Rv-CC...